Mapatumumab Antibody

SKU: orb2803560

Description

Mapatumumab (HGS-ETR1) is a fully human agonistic monoclonal antibody that binds to TRAIL-R1 (TNFRSF10A), triggering apoptosis in susceptible tumor cells. It has been investigated in preclinical and clinical studies for its potential in cancer therapy, demonstrating activity in various in vitro and in vivo models.

Key Properties

• CAS Number: 658052-09-6
• MW: 143.52 kDa
• Purity: 97.85% (SEC-HPLC)
• Target: Others

Bioactivity

• Target IC50:
  TNFRSF10A/TRAILR1 (human):17.21 ng/mL (EC50)
• In Vivo:
  Mapatumumab (10 mg/kg intrperitoneally administered twice weekly for six weeks), two neuroblastoma xenotransplantation models (NB-1643 and NB-SD) showed excessive toxicity.
• In Vitro:
  Mapatumumab (0.01-100 μg/mL) showed very limited activity against 23 cell lines of PPTP cultured in vitro, with no cell lines achieving 50% growth inhibition. Mapatumumab (1-100 ng/ml) and EPI (0.1-10 μg/ml) treated bladder cancer cells for 24 h, and showed significantly enhanced cytotoxicity and synergistic effect. Mapatumumab (100 ng/ml) does not activate T24 cells casapse-8, casapse-9 and casapse-3.

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HGS1012, HGS-1012, HGSETR1, HGS-ETR1, Anti-Human TNFRSF10A Recombinant Antibody

Quick Database Links

Gene Symbol

Others