Manidipine dihydrochloride

SKU: orb1310849

Description

Manidipine dihydrochloride

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 89226-75-5
• MW: 683.62
• Purity: 99.76%
• Formula: C₃₅H₄₀Cl₂N₄O₆
• SMILES: COC(=O)C1=C(C)NC(=C(C1c1cc(ccc1)[N+](=O)[O-])C(=O)OCCN1CCN(CC1)C(c1ccccc1)c1ccccc1)C.Cl.Cl
• Target: NF-κB,Calcium Channel
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.93 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:60 mg/mL (87.77 mM)

Bioactivity

• Target IC50:
  Ca2+ channel:2.6 nM
• In Vivo:
  In hypertensive rats, oral administration of Manidipine (3 mg/kg and 10 mg/kg) reduced systolic blood pressure in a dose-dependent manner. When administered at a dose of 10 mg/kg, Manidipine was able to normalize blood pressure within 1 to 3 hours post-administration.
• In Vitro:
  At nanomolar concentration , Manidipine effectively modulates gene transcription involved in the inflammatory transformation of mesangial cells. Manidipine inhibit the coronary artery ( IC50 9.3 nM) and renal artery ( IC50 9.1 nM). Additionally, Manidipine decreases Ca2+ flux at concentration above 0.1 nM and blocks Ca2+ flux at 100 nM.
• Cell Research:
  The mitogenic effect is measured b the amout of [3H]thymidine incorporated into DNA of human MCs and by assessment of cell proliferation. In brief, 1 × 105 quiescent cells is seeded into a 25 mL cell culture bottle and kept in low serum medium (0.1% FCS). O the following day the cells are preincubated for 3 hours with Manidipine (10 nM) followed by stimulation with PDGF-BB (10 ng/mL) or incubated with low serum medium abone the medium is replaced Each day, an the cells are counted At days 1, 3 and 5.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Manidipine, Manidipine 2HCl, Manidipine dihydrochloride, Manidipine Dihydrochloride, Inhibitor, inhibit, Ca2+ channels, Ca channels, Calcium Channel, CalciumChannel, CV 4093, CV4093, CV-4093

Compound Identifiers

PubChem CID

150762