Manidipine dihydrochloride

SKU: orb1223733

Description

A dihydropyridine type calcium channel blocker that is used as an antihypertensive.Hypertension Approved.

Key Properties

• CAS Number: 89226-75-5
• MW: 683.6213
• Purity: >98% (HPLC)
• Formula: C₃₅H₄₀Cl₂N₄O₆
• SMILES: [H+].[H+].[Cl-].[Cl-].COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)[N+]([O-])=O)C(=O)OCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
• Target: Calcium Channel
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Animal model: IFNAR-/-mice. Dosage: 10 mg/kg. Administration: Intraperitoneal injection (i.p.), b. i. d. at day 4, day 5. Result: Exhibited a modest, but statistically significant increase in the survival rate of lethal Animal model with SFTSV infection, significantly reduced viral titers in the spleen and kidney. Animal model: Adult female BALB/c mice (age, 4 weeks). Dosage: 25 mg/kg. Administration: Intraperitoneal injection (i.p.), b. i. d. for 2 days, then daily for 19 days. Result: Reduced the mortality rate from 73% to 20%, significantly reduced the viral load in infected mice while remarkably alleviated brain damage phenomena. Had little effect on peripheral JEV infection, which indicated that manidipine protected the mice against JEV-induced lethality by decreasing the viral load in the brain. Animal model: 8-week-old male Wistar rats. Dosage: 3 mg/kg. Administration: Intragastric gavage (i. g.), once per day for 7 d. Result: Prevented isoproterenol-induced left ventricular hypertrophy (2.26±0.02 g/kg; p<0.01) as isoproterenol increased left ventricular weight (2.40±0.04 g/kg; p<0.01). Inhibited expression of mRNA of ANP (0.9-fold of the control value; p<0.01), collagen types I (1.1-fold; p<0.01) and type III (1.6-fold; p<0.01), and fibronectin (1.1-fold; p<0.01).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CV-4093

Quick Database Links

Gene Symbol

Calcium Channel