Malotilate

SKU: orb1300644

Description

Malotilate

Research Area

Metabolism Research

Key Properties

• CAS Number: 59937-28-9
• MW: 288.38
• Purity: 99.79%
• Formula: C₁₂H₁₆O₄S₂
• SMILES: C(C(OC(C)C)=O)(C(OC(C)C)=O)=C1SC=CS1
• Target: Lipoxygenase
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (190.72 mM);Ethanol:58 mg/mL (201.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.94 mM)

Bioactivity

• Target IC50:
  5-LOX:4.7 μM (IC50)
• In Vivo:
  Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells.
• In Vitro:
  Malotilate caused a significant decrease in the invasion of C-SST-2 cells in RLE monolayers.Malotilate inhibited the increased permeability of RLE monolayers by serum starvation. By enhancing the intercellular contact of endothelial cells, Malotilate prevented the invasion of tumor cells into the vascular endothelium and inhibited tumor metastasis. In multilayer cultures, Malotilate (0.1-100 μM) concentration-dependently increased collagenase activity but did not affect monolayer cells. In damaged multilayer cultures, Malotilate increased MMP-1 and MMP-3 secretion, also without affecting monolayer cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Kantec, Inhibitor, Lipoxygenase, NKK 105, NKK105, NKK-105, oral, LOX, migration, injury, hepatotropic, Malotilate, Malotilatum, cell, collagen, anti-fibrotic, 5-Lipoxygenase, synthesis

Compound Identifiers

PubChem CID

4006