Malotilate

SKU: orb1224521

Description

Malotilate, diisopropyl 1,3-dithiol-2-ylidenemalonate, is a drug used for the treatment of liver cirrhosis.(In Vitro):Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro.Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.(In Vivo):Malotilate (100 mg/kg; p.o.; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol.

Key Properties

• CAS Number: 59937-28-9
• MW: 288.38
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₆O₄S₂
• SMILES: O=C(OC(C)C)/C(C(OC(C)C)=O)=C1SC=CS/1
• Target: Others
• Solubility: Ethanol: 58 mg/mL (201.12 mM); DMSO: 58 mg/mL (201.12 mM)

Bioactivity

• In Vivo:
  Malotilate (100 mg/kg; p.o. ; daily for 3 days) treatment in rats with hypocholesterolemia results in a rapid normalization of lowered serum cholesterol. Animal model: Male rats of the SLC-SD strain (rats with carbon tetrachloride-induced liver damage). Dosage: 100 mg/kg. Administration: p.o. ; daily for 3 days. Result: The triglyceride secretion from livers in rats given CCI4 was inhibited to about 40% of the level in the control rats. This inhibition of the triglyceride secretion was completely normalized in response to malotilate administration for 3 days.
• In Vitro:
  Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro. Malotilate, an anti-fibrotic substance, selectively inhibited the 5-lipoxygenase, whereas both the 12- and the 15-lipoxygenase pathways are stimulated. Malotilate has been shown to prevent acute experimental liver injury induced by several hepatotoxic compounds, including Ahyl alcohot, Bromobenzene, Carbon tetrachloride, ChIoroform, Dimethylnitrosamine and Thioacetamide.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Malotilate | CL-1500 | NKK 105 | NKK-105

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