Maleic acid

SKU: orb1302456

Description

Maleic acid acts as a glutamate decarboxylase (GAD) inhibitor in Listeria monocytogenes and Escherichia coli. This small molecule is used in research to study bacterial acid resistance mechanisms and GABA metabolism in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 110-16-7
• MW: 116.07
• Purity: 99.84% (May vary between batches)
• Formula: C₄H₄O₄
• SMILES: OC(=O)\C=C/C(O)=O
• Target: Antibacterial,Endogenous Metabolite
• Solubility: DMSO:60 mg/mL (516.93 mM);H2O:80 mg/mL (689.24 mM)

Bioactivity

• In Vitro:
  Of all compounds tested, Maleic Acid is the least inhibitory despite acting at a lower pH (4.84). The most acid resistant (10403S) and the weakest (EGD-e) strain are challenged with 8.6 mM and 4.3 mM of each organic acid at pH 3 and 3.3 respectively. On both strains, Maleic Acid is the most bactericidal.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

E. coli, Bacterial, inhibit, Inhibitor, Maleic acid, Endogenous Metabolite, EndogenousMetabolite

Compound Identifiers

PubChem CID

444266