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MAK683

SKU: orb1308347

Description

MAK683 is a potent and selective small molecule inhibitor of the Embryonic Ectoderm Development (EED) protein, with IC50 values ranging from 26 to 89 nM across multiple biochemical assays. This inhibitor is a valuable chemical probe for investigating the role of EED and PRC2 complex function in epigenetic regulation, cancer biology, and stem cell research, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number1951408-58-4
MW376.39
Purity98.16% (May vary between batches)
FormulaC20H17FN6O
SMILESCc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
TargetHistone Methyltransferase
SolubilityDMSO:4.33 mg/mL (11.5 mM)

Bioactivity

Target IC50
EED Alphascreen:59 nM|LC-MS:89 nM|ELISA:26 nM
In Vitro
After treatment 14 days, MAK683 has antiproliferative activities in B cell lymphoma cell KARPAS422 (IC50: 30 nM) .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, MAK 683, MAK683, MAK-683, LC-MS, HistoneMethyltransferase, Histone Methyltransferase, ELISA, EED Alphascreen, EED

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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Protocol Information

MAK683 (orb1308347)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 90.00
5 mg
$ 150.00
10 mg
$ 240.00
25 mg
$ 480.00
50 mg
$ 680.00
100 mg
$ 940.00
500 mg
$ 1,890.00
DispatchUsually dispatched within 3-5 working days
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