MAK683

SKU: orb1308347

Description

MAK683 is a potent and selective small molecule inhibitor of the Embryonic Ectoderm Development (EED) protein, with IC50 values ranging from 26 to 89 nM across multiple biochemical assays. This inhibitor is a valuable chemical probe for investigating the role of EED and PRC2 complex function in epigenetic regulation, cancer biology, and stem cell research, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1951408-58-4
• MW: 376.39
• Purity: 99.92%
• Formula: C₂₀H₁₇FN₆O
• SMILES: Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12
• Target: Histone Methyltransferase
• Solubility: DMSO:4.33 mg/mL (11.5 mM)

Bioactivity

• Target IC50:
  EED Alphascreen:59 nM|LC-MS:89 nM|ELISA:26 nM
• In Vitro:
  After treatment 14 days, MAK683 has antiproliferative activities in B cell lymphoma cell KARPAS422 (IC50: 30 nM) .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, MAK 683, MAK683, MAK-683, LC-MS, HistoneMethyltransferase, Histone Methyltransferase, ELISA, EED Alphascreen, EED

Compound Identifiers

PubChem CID

121412508