M8-B Hydrochloride

SKU: orb1298931

Description

M8-B Hydrochloride is a potent and selective antagonist of the TRPM8 ion channel. This compound is a valuable research tool for studying TRPM8's role in thermosensation, cold pain, and conditions like migraine and overactive bladder, in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 883976-12-3
• MW: 432.96
• Purity: 99.71% (May vary between batches)
• Formula: C₂₂H₂₅ClN₂O₃S
• SMILES: Cl.COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1
• Target: TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.62 mM);DMSO:27.5 mg/mL (63.52 mM)

Bioactivity

• In Vivo:
  M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect. It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions. M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures. M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.
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• Animal Research:
  Eight day old male Wistar rat pups were used for induction of febrile seizure. M8 B and diazepam were injected intraperitoneally. The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured. In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ). Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

M8 B Hydrochloride, M8B Hydrochloride, M-8-B Hydrochloride, M8-B Hydrochloride, TRPM8, TRPV Channel, TRPVChannel, TRP Channel, TRPChannel

Compound Identifiers

PubChem CID

69316632