M8-B Hydrochloride

SKU: orb1220124

Description

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect. It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions. M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures. M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.

Images & Validation

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Key Properties

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CAS Number	883976-12-3
MW	432.96
Purity	>98% (HPLC)
Formula	C₂₂H₂₅ClN₂O₃S?
SMILES	Cl.COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1
Target	TRP/TRPV Channel
Solubility	In Vitro: DMSO : 250 mg/mL (577.42 mM)

Bioactivity

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In Vivo	Animal model: Trpm8+/+ rats and mice. Dosage: 6 mg/kg. Administration: I. v. or i.p. Result: Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8 / mice.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

TRP/TRPV Channel

Protocol Information

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