LY334370

SKU: orb1303007

Description

LY334370

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 182563-08-2
• MW: 351.42
• Purity: 99.32%
• Formula: C₂₁H₂₂FN₃O
• SMILES: CN1CCC(CC1)c1c[nH]c2ccc(NC(=O)c3ccc(F)cc3)cc12
• Target: 5-HT Receptor
• Solubility: DMSO:50 mg/mL (142.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.69 mM)

Bioactivity

• Target IC50:
  5 hT1F:Ki: 1.6 nM
• In Vivo:
  Following intravenous administration of LY334370 at doses of 3 mg/kg ( = ) or 10 mg/kg ( = ), electrical stimulation induced increases in dural blood vessel diameter by 13 ± % and 10 ± 1%, respectively with no significant difference from control values. LY334370 does not independently affect dural blood vessel diameter, as measurements remained consistent at 4 ± arbitrary units both before and 15 minutes after a 10 mg/kg dose injection.
• In Vitro:
  LY334370 does not exhibit vasoconstrictor effects on human cerebral arteries in vitro at doses up to 10^-5 M, where it induces a minor contraction of 8. ± .7%; this effect is not considered significant.
• Cell Research:
  For in vitro studies, LY334370 is dissolved in buffer solution.Human cerebral artery is used in this study. Segments are prepared as previously described, but Briefly they are placed in a buffer solution containing (mM) NaCl 119, NaHCo3 15, KCl 4.6, CaCl2 1.5, NaH2PO4 1.2, MgCl2 1.2, and glucose 5.5. Sections of vessel about 0.5 mM in diameter and 1 to 2 mM in length are mounted in a temperature-controlled tissue bath (37°C) containing buffer solution bubbled with 95% O2 and 5% CO2 the vessel segments are given a tension of 4 mN and allowed to stabilize at this tension for 1 to 1.5 h. Vessel reactivity is tested by exposure to 60 mM KCl. This is done twice for Each segment and only in the response is similar to the segment used for LY334370 testing. Responses to LY334370 is calculated as a percentage o the maximum KC1 response.
• Animal Research:
  LY334370 is dissolved in 0.9% saline and is administered at a volume of 1 L/kg. Male Sprague Dawley rats (300 to 400 g) are treated with LY334370 (3 or 10 mg/kg, iv.).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY334370, LY-334370, LY 334370, inhibit, Inhibitor, 5HTReceptor, 5-hydroxytryptamine Receptor, 5-HT Receptor, 5-HT1F, 5HT Receptor, Serotonin Receptor

Compound Identifiers

PubChem CID

5311258