LY 334370

SKU: orb1222592

Description

LY334370 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM

Key Properties

• CAS Number: 182563-08-2
• MW: 351.42
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂FN₃O
• SMILES: O=C(NC1=CC2=C(NC=C2C3CCN(C)CC3)C=C1)C4=CC=C(F)C=C4
• Target: AChR
• Solubility: DMSO : ≥ 55.5 mg/mL; 157.93 mM

Bioactivity

• In Vivo:
  Following intravenous administration of LY334370 at 3 mg/kg (n = 3) or 10 mg/kg (n = 6) electrical stimulation evokes an increase in dural blood vessel diameter of 135±6% and 106±11%, respectively, which is not significantly different from the respective control values. LY334370 has no effect on dural blood vessel diameter per se, since the actualdural blood vessel diameter is 43±4 arbitrary units before drug and 43±4 arbitrary units 15 min after injection of LY334370 (10 mg/kg).
• In Vitro:
  LY334370 has no vasoconstrictor effects on human cerebral arteries in vitro until a dose of 10-5 M, at which it produces a contraction of 8.5±5.7%; however, this is not significant.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR