LY3295668

SKU: orb1707036

Description

LY3295668 (AK-01) is a potent and highly selective Aurora A kinase inhibitor, exhibiting sub-nanomolar affinity (Ki = 0.8 nM) for Aurora A with over 1000-fold selectivity against Aurora B. This selectivity profile makes it a valuable chemical probe for investigating mitotic progression, centrosome maturation, and tumorigenesis in both cellular and animal models of cancer.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1919888-06-4
• MW: 489.95
• Purity: 99.68% (May vary between batches)
• Formula: C₂₄H₂₆ClF₂N₅O₂
• SMILES: C[C@@H]1C[C@@](Cc2nc(Nc3cc(C)[nH]n3)ccc2F)(CCN1Cc1cccc(Cl)c1F)C(O)=O
• Target: Aurora Kinase
• Solubility: DMSO:90 mg/mL (183.69 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.74 mM)

Bioactivity

• Target IC50:
  Aurora A:0.8 nM
• In Vitro:
  LY3295668 kills Rb-deficient cancer cells with minimal effects on normal cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LY 3295668, LY3295668, LY-3295668, Aurora A, AuroraKinase, Aurora Kinase, AK01, AK-01, AK 01

Compound Identifiers

PubChem CID

121333423