LY3295668 erbumine

SKU: orb3174682

Description

LY3295668 (AK-01) erbumine is a highly selective, orally active inhibitor of Aurora-A kinase, with Ki values of 0.8 nM for AurA and 1038 nM for AurB. It effectively suppresses AurA autophosphorylation, inducing mitotic arrest and apoptosis (apoptosis), while preventing polyploidy associated with AurB inhibition. LY3295668 erbumine is applicable for studying small cell lung cancer.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1919888-07-5
• MW: 563.09
• Formula: C₂₈H₃₇ClF₂N₆O₂
• SMILES: C(C)(C)(C)N.C([C@]1(C(O)=O)C[C@@H](C)N(CC2=C(F)C(Cl)=CC=C2)CC1)C=3N=C(NC4=NNC(C)=C4)C=CC3F
• Target: Aurora Kinase,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Aurora Kinase,Apoptosis