LUPENONE

SKU: orb1301564

Description

Lupenone is a natural triterpenoid isolated from Rhizoma Musae, exhibiting significant anti-diabetic and anti-inflammatory activities. In vitro studies demonstrate it is a potent PTP1B inhibitor with an IC50 of 15.11±1.23 µM, supporting its investigation for metabolic disease research.

Research Area

Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1617-70-5
• MW: 424.7
• Purity: 99.92% (May vary between batches)
• Formula: C₃₀H₄₈O
• SMILES: CC(=C)[C@@H]1CC[C@]2(C)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CCC(=O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12
• Target: PI3K,Parasite,Phosphatase,Akt,mTOR,NF-κB
• Solubility: DMSO:Slightly soluble

Bioactivity

• Target IC50:
  PTP1B:15.11±1.23μM
• In Vivo:
  Lupenone significantly decreased acute and subacute inflammation in mice as well as the IL-1β and IFN-γ levels in the pancreas of diabetic rats.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PTP1B, LUPENONE, Parasite, Inhibitor, inhibit

Compound Identifiers

PubChem CID

92158