LUPENONE

SKU: orb1220767

Description

Lupenone is a natural product isolated from Rhizoma Musae and has good anti-diabetic activityand has anti-inflammatory activity.lupenone were potent PTP1B inhibitors with IC50 values of 15.11±1.23μM.

Key Properties

• CAS Number: 1617-70-5
• MW: 424.7
• Purity: >98% (HPLC)
• Formula: C₃₀H₄₈O
• SMILES: [H][C@]12[C@@H](CC[C@]1(C)CC[C@]1(C)[C@]2([H])CC[C@]2([H])[C@@]3(C)CCC(=O)C(C)(C)[C@]3([H])CC[C@@]12C)C(C)=C
• Target: Phosphatase
• Solubility: In Vitro: Ethanol : 10 mg/mL (23.55 mM)

Bioactivity

• In Vivo:
  Animal model: Spontaneous type 2 diabetic nephropathy db/db mouse models. Dosage: 6, 12, 24 mg/kg. Administration: i. g. Result: Maintained the fasting blood glucose. Reduced glycosylated hemoglobin, insulin, and 24 h proteinuria levels. Regulated changes in biochemical indicators.
• In Vitro:
  Cell Viability Assay Cell line: SH-SY5y. Concentration: 5, 10. 20, 40 μM Incubation time: 24 h. Result: Did not cause significant cell death at different concentrations. Apoptosis Analysis Cell line: SH-SY5y. Concentration: 40 μM. Incubation time: 1 h. Result: Reduced the population of annexinV/PI-positive cells (early apoptotic cells) and annexinV positive cells (total apoptotic cells). Western blot analysis. Cell line: SH-SY5y. Concentration: 40 μM. Incubation time: 1 h. Result: Increased the expression of anti-apoptotic proteins, including bcl-2 and caspases such as caspase 3, caspase 7, and caspase 8.Recuperate the phosphorylation level of PI3K and Akt. Inhibited the translocation of p65 from the cytosol to the nucleus, IκBα degradation, and IκBα phosphorylation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Phosphatase