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LSD1-IN-24

SKU: orb2900614

Description

LSD1-IN-24(compound 3S) is a selective LSD1 inhibitor with IC50 = 0.247 μM. LSD1-IN-24 can mediate the expression of PD-L1, enhance T cell killing response, and can be used in cancer research.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number4734-59-2
MW312.43
Purity>98% (HPLC)
FormulaC18H20N2OS
SMILESO1CCN(CC1)CCN2C=3C=CC=CC3SC=4C=CC=CC42
TargetPD-1/PD-L1
SolubilityIn Vitro: DMSO : 100 mg/mL (320.07 mM; Ultrasonic (<80°C)

Bioactivity

In Vivo
Animal model: Male 615 mice with MFC cell. Dosage: 0, 10, 25, and 50 mg/kg. Administration: Oral gavage; daily for 2 weeks. Result: Significantly decreased intratumoral PD-L1 expression, increased CD3+, CD4+, CD8+ cell numbers, interleukin-2 (IL2) and IFNγ mRNA and protein levels were also upregulated.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • LSD1-IN-24 [orb1962257]

    99.61% (May vary between batches)

    4734-59-2

    312.43

    C18H20N2OS

    1 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg
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Protocol Information

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2 mg
$ 140.00
5 mg
$ 190.00
10 mg
$ 290.00
25 mg
$ 550.00
50 mg
$ 880.00
100 mg
$ 1,310.00
500 mg
$ 2,610.00