LSD1-IN-24

SKU: orb1962257

Description

LSD1-IN-24 is a potent and selective LSD1 inhibitor (IC50 = 0.247 µM). It upregulates PD-L1 expression and potentiates T cell-mediated cytotoxicity, making it a valuable research tool for investigating cancer immunotherapy in both cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 4734-59-2
• MW: 312.43
• Purity: 99.61% (May vary between batches)
• Formula: C₁₈H₂₀N₂OS
• SMILES: O1CCN(CC1)CCN2C=3C=CC=CC3SC=4C=CC=CC42
• Target: PD-1/PD-L1,Histone Demethylase
• Solubility: DMSO:50 mg/mL (160.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.4 mM)

Bioactivity

• In Vivo:
  In a subcutaneous tumor model containing MFC cells, LSD1-IN-24 (compound 3S) (0-50 mg/kg, oral gavage; daily for 2 weeks) dose-dependently inhibits the in vivo growth of MFC cells. The tumor weight significantly decreases, Ki67 expression in tumor tissues markedly decreases, and there is no apparent toxicity observed in mice.
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• In Vitro:
  LSD1-IN-24 (compound 3S) (0-20 μM, 5 days) can dose-dependently reduce PD-L1 levels in an LSD1-dependent manner and enhance T-cell cytotoxicity against BGC-823 cells. It does not affect the proliferation of BGC-823 and MFC cells. Additionally, it can dose-dependently protect H3K4me1/2 from demethylation but cannot protect H3K4me3.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LSD1, LSD1IN24, PD1/PDL1, PD-1, PD1, HistoneDemethylase, Histone Demethylase, PDL1, PD-L1

Compound Identifiers

PubChem CID

458780