Loteprednol etabonate

SKU: orb1310863

Description

Loteprednol etabonate (Lotemax) is a synthetic corticosteroid structurally related to prednisolone, designed for ophthalmic use as a potent anti-inflammatory agent. It is widely utilized in research to model steroid responses, particularly in studies of ocular inflammation, both in vitro and in animal models.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 82034-46-6
• MW: 466.95
• Purity: 99.00% (May vary between batches)
• Formula: C₂₄H₃₁ClO₇
• SMILES: CCOC(=O)O[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]12C)C(=O)OCCl
• Target: Antibacterial,Glucocorticoid Receptor,Antibiotic
• Solubility: DMSO:50 mg/mL (107.08 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:4 mg/mL (8.57 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.35 mM)

Bioactivity

• In Vitro:
  Loteprednol possesses a metabolically labile function, the 17beta-ester, that is designed to be rapidly deactivated in the systemic circulation. Loteprednol etabonate exhibits a binding affinity which is 4.3 times that of dexamethasone, both compounds having a Hill factor close to 1 whereas PJ90 and PJ91 does not show any affinity to the receptor.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, anterior, Alrex, acute, Lotemax, Loteprednol etabonate, inhibit, Inhibitor, GlucocorticoidReceptor, Glucocorticoid Receptor, steroid, uveitis

Compound Identifiers

PubChem CID

444025