Loteprednol etabonate

SKU: orb1223940

Description

Loteprednol etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.Allergy Approved(In Vitro):Intravenous administration of Loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 82034-46-6
• MW: 466.9518
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₁ClO₇
• SMILES: O=C([C@@]1(OC(OCC)=O)CC[C@@]2([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C)=O)OCCl
• Target: GR
• Solubility: DMSO: ≥ 45 mg/mL

Bioactivity

• In Vivo:
  Intravenous administration of Loteprednol etabonate (5 mg/kg) to dogs reveals a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Loteprednol Etabonate | Lotemax | Alrex | HGP-1 | Loterox | Locort

Quick Database Links

Gene Symbol

GR