Lonidamine

SKU: orb1310804

Description

Lonidamine is an indazole-carboxylic acid derivative that targets mitochondrially-bound hexokinase to inhibit aerobic glycolysis. It is widely used in cancer metabolism research, demonstrating effects in both in vitro cell studies and in vivo tumor models to investigate energy disruption strategies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research

Key Properties

• CAS Number: 50264-69-2
• MW: 321.16
• Purity: 97.90% (May vary between batches)
• Formula: C₁₅H₁₀Cl₂N₂O₂
• SMILES: OC(=O)c1nn(Cc2ccc(Cl)cc2Cl)c2ccccc12
• Target: Apoptosis,Mitochondrial Metabolism,Parasite,Hexokinase
• Solubility: DMSO:60 mg/mL (186.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.23 mM);Ethanol:1.6 mg/mL (4.98 mM)

Bioactivity

• Target IC50:
  Mitochondrial pyruvate carrier:2.5 μM (Ki)
• In Vivo:
  In both normal and tumor cells, Lonidamine reduces oxygen consumption while augmenting aerobic glycolysis in normal cells, thereby inhibiting aerobic glycolysis in tumor cells. The compound induces apoptosis at a concentration of 50 mg/ml in resistant cell lines, including the human breast cancer cell line MCF-7 ADR(r) and the LB9 multiform glioblastoma cell line, which exhibit resistance to doxorubicin and nitrosourea.
• In Vitro:
  In mice carrying glioma tumors, Lonidamine (160 mg/kg) effectively reduced tumor growth.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diclondazolic Acid, DICA, Apoptosis, A549, AF1890, AF-1890, AF 1890, Lonidamine, inhibit, Mitochondrial, mitochondrial complex, MitochondrialMetabolism, Mitochondrial Metabolism, lung fibrosis, Hexokinase, hexokinase, Inhibitor, lactate, H2030BrM3, pulmonary fibrosis

Compound Identifiers

PubChem CID

39562