LJH685

SKU: orb1223259

Description

LJH685 is an effective pan-RSK inhibitor for RSK1/2/3 (IC50: 6/5/4 nM).

Key Properties

• CAS Number: 1627710-50-2
• MW: 381.42
• Purity: >98% (HPLC)
• Formula: C₂₂H₂₁F₂N₃O
• SMILES: CN1CCN(CC1)c1ccc(cc1)c1ccncc1c1cc(F)c(O)c(F)c1
• Target: HCV
• Solubility: DMSO : ≥ 31 mg/mL 81.28 mM

Bioactivity

• In Vitro:
  LJH685 (0.01-100 μM; 72 hours) efficiently inhibits the growth of MDA-MB-231 and H358 cells in soft agar with EC50s of 0.73 and 0.79 μM, respectively. LJH685 (0.1-10 μM; 4 hours) efficiently reduces phosphorylation of YB1 at submicromolar concentrations and causes nearly complete inhibition at higher concentrations. Cell Proliferation Assay Cell line: MDA-MB-231, H358 cells. Concentration: 0.01, 0.1, 1, 10, 100 μM Incubation time: 72 hours. Result: The growth in soft agar was efficiently inhibited with EC50 values of 0.73 and 0.79 μM in MDA-MB-231 and H358, respectively. Western blot analysis. Cell line: MDA-MB-231, H358 cells. Concentration: 0.1, 0.3, 1, 3, 10 μM Incubation time: 4 hours. Result: Efficiently reduced phosphorylation of YB1 at submicromolar concentrations and caused nearly complete inhibition at higher concentrations.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LJH685 | NVP-LJH685 | NVP LJH685

Quick Database Links

Gene Symbol

HCV