LIT-001

SKU: orb1309476

Description

LIT-001 is a novel, nonpeptide oxytocin receptor agonist (Ki = 226 nM, EC50 = 55 nM) shown to enhance social interaction in a murine autism model. This small molecule tool compound is valuable for in vitro binding assays and in vivo behavioral studies investigating oxytocin pathway function in neuropsychiatric research.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2245072-21-1
• MW: 645.7
• Purity: 98.25% (May vary between batches)
• Formula: C₃₀H₃₄F₃N₇O₄S
• SMILES: OC(=O)C(F)(F)F.CN(C)C(=S)[C@@H]1CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1Cc2cnn(C)c2Nc2ccccc12
• Target: Oxytocin Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (7.74 mM);DMSO:247 mg/mL (382.53 mM)

Bioactivity

• Target IC50:
  OTR:226 nM (Ki)|OTR:55 nM (EC50)
• In Vivo:
  LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms of autism spectrum disorders (ASD) .
• In Vitro:
  In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

spectrum, social, OXTR, OxytocinReceptor, oxytocin receptor, Oxytocin Receptor, OT-R, receptor, V1a, vasopressin, interaction, nonbiased, Inhibitor, nonpeptide, LIT001, LIT-001, LIT 001, inhibit, autism, disorders

Compound Identifiers

PubChem CID

145711713