LIT-001

SKU: orb1219619

Description

LIT-001 improves social interaction in a mouse model of autism.It is the first nonpeptide oxytocin receptor agonist with EC50 of 55 nM and Ki of 226 nM.In the in vitro signal transduction experiment, LITL-001 is an unbiased OT-R agonist, acting on the two main signal transduction pathways of this receptor, with slight antagonistic effect on V1a and agonist effect on V1b receptor, only observed at high concentration.LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD).

Key Properties

• CAS Number: 2245072-21-1
• MW: 645.7
• Purity: >98% (HPLC)
• Formula: C₃₀H₃₄F₃N₇O₄S
• SMILES: OC(=O)C(F)(F)F.CN(C)C(=S)[C@@H]1CCCN1C(=O)NCc1ccc(cc1C)C(=O)N1Cc2cnn(C)c2Nc2ccccc12
• Target: oxytocin receptor
• Solubility: DMSO:247 mg/mL (382.53mM; Need ultrasonic)

Bioactivity

• In Vivo:
  LIT-001 (10-20 mg/kg; i.p.) alleviates core symptoms in the context of autism spectrum disorders (ASD). Animal model: Oprm1–/– mice (bred in house on a 50% 129SVPas–50% C57BL/6J hybrid background). Dosage: 10, 20 mg/kg. Administration: i.p. Result: Alleviated core symptoms in the context of ASD.
• In Vitro:
  In vitro signaling experiments, LIT-001 is a nonbiased OT-R agonist on the two main signaling pathways of this receptor, with minor antagonist effect on V1a and agonist effect on V1b receptors, observed at high concentrations only.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

oxytocin receptor