Liranaftate

SKU: orb1223744

Description

Liranaftate is a squalene epoxidase inhibitor with anti-fungicidal activities.(In Vitro):Liranaftate showed excellent fungistatic activity against the conidia of T. rubrum. For each of these agents, the MIC after 14 days of contact was 0.009 g/ml. The liranaftate-induced decrease in the MCC occurred from 9 days onwards; MCC at 14 days was 0.039 g/ml . In time-kill studies, liranaftate showed the greatest decrease to a below detection limit in viable counts of T rubrum. The degree of killing of the strain by amorolfine was not greater than that seen by liranaftate, and little reduction of the viable counts by luliconazole and ketoconazole was observed irrespective of concentrations of the agents .

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 88678-31-3
• MW: 328.43
• Purity: >98% (HPLC)
• Formula: C₁₈H₂₀N₂O₂S
• SMILES: O=C(OC1=CC=C2CCCCC2=C1)N(SC)C3=NC(OC)=CC=C3
• Target: Antifungal
• Solubility: DMSO: >5mM

Bioactivity

• In Vitro:
  Liranaftate showed excellent fungistatic activity against the conidia of T. rubrum. For each of these agents, the MIC after 14 days of contact was 0.009 g/ml. The liranaftate-induced decrease in the MCC occurred from 9 days onwards; MCC at 14 days was 0.039 g/ml. In time-kill studies, liranaftate showed the greatest decrease to a below detection limit in viable counts of T rubrum. The degree of killing of the strain by amorolfine was not greater than that seen by liranaftate, and little reduction of the viable counts by luliconazole and ketoconazole was observed irrespective of concentrations of the agents.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Liranaftate | M-732 | Piritetrate

Quick Database Links

Gene Symbol

Antifungal