S14

SKU: orb1785944

Description

Lipidoid S14 is a novel lipidoid for siRNA delivery.Lipidoid-polymer hybrid nanoparticle (FS14-NP) can efficiently deliver siRNA against IL-1β (siIL-1β) to macrophages and effectively suppress the pathogenesis of experimental arthritis induced by collagen antibody (CAIA mice). FS14-NP/siIL-1β achieved approximately 70% and 90% gene-silencing efficiency in the RAW 264.7 cell line and intraperitoneal macrophages, respectively. Intravenous administration of FS14-NP/siRNA led to rapid accumulation of siRNA in macrophages within the arthritic joints. Furthermore, FS14-NP/siIL-1β treatment lowered the expression of pro-inflammatory cytokines in arthritic joints and dramatically attenuated ankle swelling, bone erosion, and cartilage destruction.

Key Properties

• CAS Number: 2349307-29-3
• MW: 994.73
• Formula: C₆₃H₁₃₁N₃O₄
• SMILES: CCCCCCCCCCCCC(O)CN(CCCCNCCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC

Storage & Handling

• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only