Licochalcone A

SKU: orb1224571

Description

Licochalcone A exhibits potent antimalarial activity via and might be developed into a new antimalarial drug. Licochalcone A had anti-tumor activity in all cell lines tested and enhanced the effect of paclitaxel and vinblastine chemotherapy. Licochalcone A induced apoptosis in MCF-7 and HL-60 cell lines, as demonstrated by cleavage of PARP, the substrate of ICE-like proteases. Licochalcone A exhibits a strong antileishmanial activity ,that appropriate substituted chalcones might be a new class of antileishmanial drugs.(In Vitro):Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .

Key Properties

• CAS Number: 58749-22-7
• MW: 338.4
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₂O₄
• SMILES: O=C(C1=CC=C(O)C=C1)/C=C/C2=CC(C(C)(C)C=C)=C(O)C=C2OC
• Target: Caspase
• Solubility: Soluble in DMSO, Chloroform

Bioactivity

• In Vitro:
  Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Licochalcone A | Licochalcone-A

Quick Database Links

Gene Symbol

Caspase