Licochalcone A

SKU: orb1304012

Description

Licochalcone A is a bioactive flavonoid derived from Glycyrrhiza uralensis (licorice) root. It exhibits significant anti-cancer properties in vitro, including the induction of apoptosis and cell cycle arrest, and has shown promising anti-tumor effects in various in vivo xenograft models.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 58749-22-7
• MW: 338.40
• Purity: 99.65% (May vary between batches)
• Formula: C₂₁H₂₂O₄
• SMILES: COc1cc(O)c(cc1\C=C\C(=O)c1ccc(O)cc1)C(C)(C)C=C
• Target: Autophagy,UGT,Caspase
• Solubility: Chloroform:Soluble;H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:250.00 mg/mL (738.77 mM);15% Cremophor EL:5.00 mg/mL (14.78 mM);Ethanol:67.00 mg/mL (197.99 mM)

Bioactivity

• Target IC50:
  UGT1A1:0.97 μM
• In Vivo:
  In mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, licochalcone A (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. In CT-26 cell-inoculated Balb/c mice, licochalcone A (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity.
• In Vitro:
  Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis. Licochalcone A also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis.
• Cell Research:
  The viability of CT-26 mouse colon cancer cells is determined via a MTT assay. In brief, colon cancer cells are seeded onto each well of a 96-well plate with DMEM containing 10% FBS and cultured to adhere overnight. The cells are then treated with various concentrations of LCA in serum-free medium for 24 and 72 hr, respectively. Twenty microlitres of a MTT solution (5 mg/ml) is added to each well, and the cells are incubated for 4 hr at 37°. The medium is then removed, and 200 μL of dimethyl sulfoxide is added to each well. The absorbance is determined at 570 nm using a microplate reader.(Only for Reference)

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

UGT1A1, Autophagy, Caspase-3, inhibit, Licochalcone A, Licochalcone-A, Inhibitor

Compound Identifiers

PubChem CID

5318998