LH846

SKU: orb1307282

Description

LH846 is a potent and selective casein kinase 1 delta (CK1δ) inhibitor with an IC50 of 290 nM, showing significantly lower activity against CK1ε, CK1α, and no effect on CK2. This tool compound is used in vitro and in vivo to study circadian rhythms, Wnt signaling, and cancer research pathways dependent on CK1δ activity.

Research Area

Metabolism Research, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 639052-78-1
• MW: 316.81
• Purity: 98.26% (May vary between batches)
• Formula: C₁₆H₁₃ClN₂OS
• SMILES: Cc1cc2sc(NC(=O)Cc3ccccc3)nc2cc1Cl
• Target: Casein Kinase
• Solubility: DMSO:55 mg/mL (173.61 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (7.89 mM)

Bioactivity

• Target IC50:
  CK1ε:1.3 μM|CK1α:2.5 μM|CK1δ:290 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CaseinKinase, Casein Kinase, CK1, Inhibitor, LH 846, LH846, LH-846, inhibit

Compound Identifiers

PubChem CID

851474