LH-846

SKU: orb1224380

Description

LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.

Key Properties

• CAS Number: 639052-78-1
• MW: 316.81
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₃ClN₂OS
• SMILES: O=C(NC1=NC2=CC(Cl)=C(C)C=C2S1)CC3=CC=CC=C3
• Target: Casein Kinase
• Solubility: DMSO: 45 mg/mL

Bioactivity

• In Vitro:
  LH846 is a potent inhibitor of CKIδ, with an IC50 of 290 nM, less potently inhibits CKIα and CKIε, with IC50s of 2.5 μM and 1.3 μM, respectively, and has no effect on CK2. LH846 (3 or 10 μM) inhibits CKIδ-dependent phosphorylation of PER1 in HEK293T cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LH846 | LH-846 | LH 846

Quick Database Links

Gene Symbol

Casein Kinase