LGR5 Antibody (loop2)

SKU: orb34046

Description

Rabbit polyclonal antibody to LGR5 (Leucine-rich repeat G protein-coupled receptor 5) is thought of as a possible stem cell marker for the hair follicle and the epithelium of the intestine. LGR5 is only expressed in cycling crypt base columnar cells, which are thought to be genuine intestinal stem cells. LGR5 has also been implicated as a negative regulator of the Wnt signaling pathway. LGR5 is often up-regulated in certain cancers and may play a role in cancer cell progression.

Research Area

Cancer Biology, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

• Tested Applications: FC, WB
• Dilution Range: WB - 1:1000, IF - 1:100, FC - 1:25
• Reactivity: Human, Mouse, Rat

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Immunogen: Synthetic Peptide
• Target: LGR5
• Molecular Weight: 99998
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
• Form/Appearance: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Anti-Leucine-rich repeat-containing G-protein coupled receptor 5 [Precursor] antibody, anti-Orphan G-protein coupled receptor HG38 antibody, anti-G-protein coupled receptor 49 antibody, anti-G-protein coupled receptor 67 antibody, anti-LGR5 antibody, anti-GPR49 antibody, anti-GPR67 antibody

Quick Database Links

Gene Symbol

LGR5

UniProt

O75473

RefSeq (Protein):NP_001264155.1, NP_003658.1