Levonorgestrel

SKU: orb1223984

Description

Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 797-63-7
• MW: 312.45
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₈O₂
• SMILES: CC[C@]12CC[C@H]3[C@@H](CCC4=CC(CC[C@H]34)=O)[C@@H]1CC[C@@]2(O)C#C
• Target: Estrogen Receptor/ERR
• Solubility: Ethanol: 2 mg/mL (6.4 mM); DMSO: 45 mg/mL (144.02 mM)

Bioactivity

• In Vivo:
  Animal model: Apodemus agrarius model. Dosage: 1 mg/kg. Administration: Intragastric administration (i. g.), Once daily for three days. Result: Damaged the sperm ducts, reduced sperm production in combination with quinestrol. Reduced population density in the field in combination with quinestrol.
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• In Vitro:
  Western blot analysis. Cell line: Uterine leiomyoma cells. Concentration: 5 mg/mL; 10 mg/mL; 20 mg/mL. Incubation time: Result: Inhibited Bcl-2 and survivin expression at high concentrations (10 mg/mL and 20 mg/mL). Significantly increased the phosphorylation of P38 phosphorylation and increased Caspase-3 expression at high concentrations (10 mg/mL and 20 mg/mL).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Levonorgestrel, Norgestrel, Microval, Postinor, Mirena, Plan B

Quick Database Links

Gene Symbol

Estrogen Receptor/ERR