Levodropropizine

SKU: orb1310823

Description

Levodropropizine is the (S)-(-)-enantiomer of dropropizine, acting as a histamine receptor inhibitor. This well-tolerated peripheral antitussive is used in research to investigate cough mechanisms in both in vitro receptor studies and in vivo animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 99291-25-5
• MW: 236.31
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₂₀N₂O₂
• SMILES: C([C@@H](CO)O)N1CCN(CC1)C2=CC=CC=C2
• Target: 5-HT Receptor,Histamine Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.46 mM);DMSO:55 mg/mL (232.75 mM);Ethanol:44 mg/mL (186.2 mM);H2O:12 mg/mL (50.78 mM)

Bioactivity

• In Vivo:
  Levodropropizine exhibits affinity for both H1 histamine and α-adrenergic receptors.
• In Vitro:
  Research indicates that Levodropropizine effectively suppresses cough in anesthetized guinea pigs and rabbits. Intravenous administration of Levodropizine in these animals, during mechanically and electrically induced coughs, shows an activity ranging from one-tenth to one-twentieth of codeine, similar to hydroxyzine. Oral Levodropizine treatment for cough induced by irritant aerosols has effects comparable to hydroxyzine and codeine. An intravenous dose of 15 mg/kg Levodropropizine reduces the duration of asphyxiation and the C-fiber response to phenylbiguanide. Additionally, Levodropropizine dose-dependently decreases capsaicin-induced Evans blue dye extravasation in rat airways.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dropropizine, DF 526, DF526, DF-526, (S)-(-)-Dropropizine, 5HT Receptor, 5HTReceptor, Inhibitor, HT, Levodropropizine, HistamineReceptor, Histamine Receptor, inhibit

Compound Identifiers

PubChem CID

65859