Levodropropizine

SKU: orb1223469

Description

Levodropropizine is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 99291-25-5
• MW: 236.31
• Purity: >98% (HPLC)
• Formula: C₁₃H₂₀N₂O₂
• SMILES: OC[C@@H](O)CN1CCN(C2=CC=CC=C2)CC1
• Target: 5-HT Receptor
• Solubility: Ethanol: 47 mg/mL (198.89 mM); Water: 15 mg/mL (63.47 mM); DMSO: 47 mg/mL (198.89 mM)

Bioactivity

• In Vivo:
  Animal model: Pentylenetetrazol (PTZ)-induced status epilepticus in rats. Dosage: 20 and 40 mg/kg. Administration: i.p. Result: Decreased Mean electroencephalogram (EEG) spike wave percentage score from 76.8% (placebo) to 13.1% (lower dose) and 7.6% (higher dose). Decreased Racine's Convulsion Scale (RCS) from a mean of 5.8 (placebo) to 1.83 (lower dose) and 1.16 (higher dose). Increased time to first myoclonic jerk (TFMJ) from a mean of 65.1 s (placebo), to 247.3 s (lower dose) and 295.5 s (higher dose).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Levodropropizine | DF 526 | DF-526 | DF526 | Levotuss

Quick Database Links

Gene Symbol

5-HT Receptor