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Levodopa

SKU: orb1224522

Description

L-DOPA is a natural form of DOPA used in the treatment of Parkinson disease. L-DOPA is the precursor of dopamine and product of tyrosine hydroxylase.

Research Area

Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number59-92-7
MW197.19
Purity>98% (HPLC)
FormulaC9H11NO4
SMILESC1=CC(=C(C=C1C[C@@H](C(=O)O)N)O)O
TargetDopamine Receptor
SolubilityEthanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

Bioactivity

In Vivo
Animal model: 7-week-old C57BL/6J mice. Dosage: 20 mg/kg. Administration: Orally. Result: Reduced Rotenone-induced motor dysfunction. Animal model: Sprague-Dawley rats (male 100-150 g). Dosage: 10, 30, 50, 70, and 100 mg/kg. Administration: Orally. Result: Reverses tactile, cold and heat allodynia in neuropathic rat without any side effect.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

3,4-Dihydroxyphenylalanine | Levodopa

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Protocol Information