LD2

SKU: orb3027414

Description

LD2 is a protein arginine methyltransferase 9 (PRMT9; IC50 = 0.9 µM) inhibitor. It can reduce the proliferation ability of Rec-1 and Raji lymphoblast cells, UPN1 mantle cell lymphoma, BL-41 Burkitt lymphoma, and OCI-Ly3 diffuse large B-cell lymphoma (DLBCL) cells (IC50s = 2.5-5 µM). LD2 (2.5 µM) can induce G2/M phase cell cycle arrest in THP-1 acute myeloid leukemia (AML) cells and reduce the phosphorylation levels of checkpoint kinases 1 (Chk1) and Chk2 in their cells.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 1134334-55-6
• MW: 247.68
• Formula: C₁₂H₁₀ClN₃O
• SMILES: ClC1=NC=NC=2C=3C=C(OC)C=CC3N(C12)C
• Target: Histone Methyltransferase,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Histone Methyltransferase,Others