lavendustin C

SKU: orb1223359

Description

Lavendustin C, also known as HDBA and NSC 666251, is a potent inhibitor of epidermal growth factor (EGF) receptor-associated tyrosine kinase with an IC50 value of 0.012 μM.. HDBA inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.

Key Properties

• CAS Number: 125697-93-0
• MW: 275.26
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₃NO₅
• SMILES: O=C(O)c1cc(NCc2cc(O)ccc2O)ccc1O
• Target: Raf
• Solubility: In Vitro: DMSO : 100 mg/mL (363.29 mM)

Bioactivity

• In Vitro:
  Lavendustin C (Compound 5) shows potent inhibitory activity, and it may be the core structure responsible for inhibition of tyrosine kinase. Lavendustin C (10-150 μM) inhibits tyrosine kinase-associated neutrophil degranulation and superoxide generation.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lavendustin C | HDBA, NSC 666251

Quick Database Links

Gene Symbol

Raf