Lauroseptol

SKU: orb1224632

Description

Cetrimonium Bromide is a known component of the broad-spectrum antiseptic cetrimide, which is a mixture of different quaternary ammonium salts.

Key Properties

• CAS Number: 57-09-0
• MW: 364.46
• Purity: >98% (HPLC)
• Formula: C₁₉H₄₂BrN
• SMILES: CCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]
• Target: Others
• Solubility: Ethanol: 100 mg/mL (274.38 mM); Water: 100 mg/mL (274.38 mM); DMSO: 5 mg/mL (13.71 mM)

Bioactivity

• In Vivo:
  Animal model: FaDu cells tumor-bearing mice. Dosage: 5 mg/kg. Administration: Intraperitoneal injection (i.p.). Result: Induced a modest reduction in tumor development. Delayed the mean time to reach a tumor-plus-leg diameters (TLD) of 14mm by ~3.7 days. Animal model: Sprague-Dawley rats. Dosage: 10 mg/kg, 20 mg/kg, 45 mg/kg. Administration: Supplemented in drinking water. Result: Showed lower body weight at highest concentration within 3 weeks. Reduced the body weight throughout the experimental in males and skeletal growth at highest dose level in both males and females. Significantly decreased efficiency of food conversion in male rats receiving the highest dose.
• In Vitro:
  Cetrimonium bromide (1-5 μM, 24 h) cannot affect growth of SK-HEP-1 cells. Cetrimonium bromide (5 μM, 16-24 h) attenuates cellular migration and invasion of SK-HEP-1cells. Cetrimonium bromide (5 μM, 24 h) inhibits the protein expression of MMP-2 and MMP-9, increases the protein expression of TIMP-1 and TIMP-2 and restrain the protein expression of Rac1, cdc42 and RhoA in SK-HEP-1cells. Cetrimonium bromide (5 μM, 12-72 h) induces apoptosis in human Head and neck cancer (HNC) cells. Cell Viability Assay Cell line: SK-HEP-1 cells. Concentration: 1 μM, 2.5 μM, 5 μM Incubation time: 24 h. Result: Retained more than 90% cell viability at 24 hours. Cell Cycle Analysis Cell line: HNC cells. Concentration: 5 μM. Incubation time: 12 h, 24 h, 48 h, 72 h. Result: Induced caspase activation. Observed the activation of the caspase cascade and increased in a time-dependent manner. Western blot analysis. Cell line: SK-HEP-1 cells. Concentration: 1 μM, 2.5 μM, 5 μM Incubation time: 24 h. Result: Significantly down-regulates MMP-2 and MMP-9 expressions in SK-HEP-1 cells in a dose-dependent manner. Significantly increased the protein expression of TIMP-1 and TIMP-2.Negatively affects the protein levels of Rac1, cdc42 and RhoA in SK-HEP-1 cells.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cetrimonium bromide | NSC 32927 | NSC-32927 | NSC32927

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Others