Cetrimonium bromide

SKU: orb1310555

Description

Cetrimonium bromide, also known as Lauroseptol, is a mixture of quaternary ammonium salts that constitutes the active ingredient in the antiseptic cetrimide. It is widely used in biochemical research for its antimicrobial properties in both in vitro microbiological studies and as a topical antiseptic in vivo models.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 57-09-0
• MW: 364.46
• Purity: 98.00%
• Formula: C₁₉H₄₂BrN
• SMILES: [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C
• Target: TGF-beta/Smad,MMP,Antibiotic,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.74 mM);H2O:100 mg/mL (274.38 mM);Ethanol:93 mg/mL (255.17 mM);DMSO:10 mg/mL (27.44 mM)

Bioactivity

• In Vivo:
  Cetrimonium Bromide exhibits a dose-dependent and radiation potentiating interaction that inhibits the clonogenic survival of FaDu cells. It induces nuclear pyknosis and bubbling in FaDu cells, consistent with the morphology of apoptotic nuclei, which is not observed in CTAB-treated GM05757 cells. Additionally, it reproducibly suppresses ATPase activity in FaDu cells, achieving approximately 90% inhibition at 50 μM. Cetrimonium Bromide reduces the cell viability in a variety of cell lines including FaDu, C666-1, UTSCC-8A, UTSCC-42A, MRC5, and GM05757 fibroblasts, with respective EC50 values of 2 μM, 3.8 μM, 3.5 μM, 4.2 μM, 11 μM, and 18 μM. It also diminishes the cell viability of A549 lung and MCF7 breast cancer cells with EC50 values of 17 μM and 12 μM, respectively.
• In Vitro:
  In a FaDu xenograft tumor model established in SCID mice, intraperitoneal administration of 5 mg/kg Cetrimonium Bromide daily for five consecutive days moderately inhibited tumor growth as compared to the vehicle treatment arm. Additionally, 5 μM of Cetrimonium Bromide effectively prevented tumor formation in FaDu cells within SCID mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Cetrimonium, Cetrimonium bromide, Cetrimonium Bromide, Cetyltrimethylammonium, Cetyltrimethylammonium Bromide, CTAB, Antibiotic, inhibit, Inhibitor, Lauroseptol, Hexadecyltrimethylammonium

Compound Identifiers

PubChem CID

5974