LAT1-IN-1

SKU: orb1309496

Description

LAT1-IN-1 (BCH) is a potent, selective, and competitive inhibitor of the L-type amino acid transporter 1 (LAT1). It exhibits antitumor properties by inhibiting cancer cell proliferation and inducing apoptosis, making it a valuable tool for studying LAT1 function in oncology research both in vitro and in vivo.

Research Area

Cell Biology

Key Properties

• CAS Number: 20448-79-7
• MW: 155.19
• Purity: 99.94%
• Formula: C₈H₁₃NO₂
• SMILES: NC1(CC2CCC1C2)C(O)=O
• Target: Apoptosis
• Solubility: DMSO:1.6 mg/mL (10.31 mM);H2O:50 mg/mL (322.19 mM)

Bioactivity

• In Vivo:
  LAT1-IN-1 (200 mg/kg; intravenous injection; daily; for 14 days; male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.
• In Vitro:
  LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.LAT1-IN-1 (1-100 mM; 3 days; KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner. LAT1-IN-1 (30 mM; 24 and 48 hours; KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase.

Storage & Handling

• Storage: keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, LAT1, LAT1 IN 1, LAT1IN1, LAT-1-IN-1, LAT1-IN-1, Inhibitor, BCH, Apoptosis

Compound Identifiers

PubChem CID

115288