LAT (C2) Antibody, Rabbit Polyclonal

SKU: orb67078

Description

Rabbit polyclonal to LAT.Linker for activation of T-cells family member 1 (LAT) is a single-pass type III cell membrane protein.LAT is required for TCR (T-cell antigen receptor)-and pre-TCR-mediated signaling, both in mature Tcellsand during their development. LAT is involved in FCGR3 (low affinity immunoglobulin gamma Fcregion receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulinepsilon receptor)-mediated signaling in mast cells. LAT couples activation of these receptors and theirassociated kinases with distal intracellular events, such as mobilization of intracellular calcium stores,PKC activation, MAPK activation or cytoskeletal reorganization through the recruient of PLCG1,GRB2, GRAP2 and other signaling molecules.

Research Area

Epigenetics, Immunology

Images & Validation

• Tested Applications: WB
• Dilution Range: WB:1:1000-1:3000
• Reactivity: Mouse

Key Properties

• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: C-terminal region of mouse LAT
• Molecular Weight: 26
• Purity: Affinity purification
• Conjugation: Unconjugated

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 0.01% NaN3
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

anti-LAT antibody,anti-Linker for activation of Tcells family member 1 antibody,anti-36 kDa phosphotyrosine adapter protein antibody,anti-pp36 antibody,anti-p36 38 antibody

Quick Database Links

UniProt

O54957