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L1CAM Antibody / NCAM-L1 / CD171
Catalog Number: orb2636042
| Catalog Number | orb2636042 |
|---|---|
| Category | Antibodies |
| Description | L1 (L1 cell adhesion molecule) also known as CAML1, CD171, and HSAS is an adhesion molecule which plays an important role in the nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). This mouse monoclonal antibody recognizes the sequence immediately NH2-terminal to the tyrosine-based motif and binds L1 only when Y1176 is dephosphorylated. Phosphorylation of either T1172 or Y1176 strongly inhibits binding of 74-5H7 to the L1 cytoplasmic domain. |
| Clonality | Recombinant |
| Species/Host | Mouse |
| Isotype | Mouse IgG2b, kappa |
| Conjugation | Unconjugated |
| Reactivity | Human |
| Immunogen | Recombinant full-length human L1CAM protein was used as the immunogen for the recombinant L1CAM antibody. |
| UniProt ID | P32004 |
| Tested applications | IHC-P |
| Dilution range | Immunohistochemistry (FFPE): 1-2ug/ml |
| Application notes | Optimal dilution of the recombinant L1CAM antibody should be determined by the researcher. |
| Antibody Type | Primary Antibody |
| Clone Number | rL1CAM/9163 |
| Formula | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Hazard Information | This recombinant L1CAM antibody is available for research use only. |
| Note | For research use only |
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