L189

SKU: orb1302793

Description

L189 is a potent and selective inhibitor of human DNA ligases I, III, and IV, with IC50 values of 5, 9, and 5 µM, respectively. It is a valuable chemical tool for studying DNA repair mechanisms in vitro and has been used in research exploring the cellular response to replication stress and DNA damage.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 64232-83-3
• MW: 246.29
• Purity: 99.72% (May vary between batches)
• Formula: C₁₁H₁₀N₄OS
• SMILES: Nc1[nH]c(=S)[nH]c(=O)c1N=Cc1ccccc1
• Target: DNA/RNA Synthesis|||DNA
• Solubility: H2O:Insoluble;DMSO:50 mg/mL (203.01 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.12 mM);Ethanol:1 mg/mL (4.06 mM)

Bioactivity

• Target IC50:
  DNA ligase I:5 µM|DNA ligase III:9 µM|DNA ligase IV:5 µM
• In Vitro:
  L189 inhibits DNA ligases I, III and IV in DNA joining assays with purified proteins and in cell extract assays of DNA replication, base excision repair and non-homologous end joinging. L189 markedly increases killing of HCT116 colon cancer cells and the other cancer cell lines by ionizing radiation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L 189, inhibit, L189, L-189, Inhibitor, cancer, DNA/RNA Synthesis, DNA Synthesis, DNALigase IV, DNASynthesis, DNA ligase, DNA Ligase I, DNA Ligase III, DNA Ligase IV, cytotoxicity, cell death, TMZ, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

824710