L-Mimosine

SKU: orb1224929

Description

L-Mimosine is a non-protein amino acid, and acts as an iron chelator.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 500-44-7
• MW: 198.18
• Purity: >98% (HPLC)
• Formula: C₈H₁₀N₂O₄
• SMILES: O=C(O)[C@@](N)(N(C=C1)C=CC1=O)CO
• Target: Others
• Solubility: DMSO:0.01 mg/mL (0.05 mM); Ethanol:<1 mg/mL (<1 mM); Water:<1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Mimosine (30, and 60 mg/kg) decreases sperm concentration. Animal model: ICR male mice (6-8 weeks). Dosage: 15, 30, or 60 mg/kg. Administration: Injected (i.p.) for 7 consecutive days. Result: Could significantly reduce sperm concentration as compared to the control or low dose mimosine group (15 mg/kg) at doses of 30 and 60 mg/kg.
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• In Vitro:
  Mimosine, a known chelator of Fe(III), may facilitate Fe(III) uptake in leucaena by serving as a phytosiderophore. Mimosine, a bidentate iron-binding ligand, may also play a role in cellular translocation of iron within leucaena. Mimosine is a toxic nonprotein amino acid that is a major constituent of the tropical legumesLeucaenaandMimosa. Mimosine (400 μM), through iron chelation, reversibly blocks cell cycle progression in MDA-MB-453 human breast cancer cells. Mimosine (400 μM) reduces DNA synthesis by greater than 90% of control within 4 hr of treatment, and suppresses total proline-directed protein kinase activity to less than 10% of control after 16 hr treatment.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Leucenol | NSC 69188

Quick Database Links

Gene Symbol

Others