L-(-)-α-Methyldopa

SKU: orb1224680

Description

Methyldopa is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive.(In Vivo):Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment.

Key Properties

• CAS Number: 555-30-6
• MW: 211.21
• Purity: >98% (HPLC)
• Formula: C₁₀H₁₃NO₄
• SMILES: O=C(O)[C@@](C)(N)CC1=CC=C(O)C(O)=C1
• Target: Dopamine Receptor
• Solubility: Ethanol: <1 mg/mL (<1 mM); Water: <1 mg/mL (<1 mM); DMSO: <1 mg/mL (<1 mM)

Bioactivity

• In Vivo:
  Methyldopa (L-(-)-α-Methyldopa; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. Animal model: 60-day-old male rats. Dosage: 200 mg/kg. Administration: i.p. Result: Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Methyldopa | MK-351 | NSC 169916

Quick Database Links

Gene Symbol

Dopamine Receptor