L-Glutamic acid monosodium salt

SKU: orb1300390

Description

Monosodium glutamate (MSG) is a selective agonist for the metabotropic glutamate receptor 1 (mGlu1). It is widely used in neuroscience research to study glutamatergic signaling, synaptic plasticity, and receptor function in both cellular and animal models.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 142-47-2
• MW: 169.11
• Purity: 99.93% (May vary between batches)
• Formula: C₅H₈NO₄·Na
• SMILES: [Na+].N[C@@H](CCC(O)=O)C([O-])=O
• Target: Apoptosis,Endogenous Metabolite,GluR,iGluR,Ferroptosis
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:115 mg/mL (680.03 mM)

Bioactivity

• In Vivo:
  Daily L-Glutamic acid monosodium salt(MSG) dietary consumption reduces pancreatic β-cell mass and enhances hemorrhages and fibrosis, but does not affect glucose homeostasis. High dietary MSG intake may exert a negative effect on the pancreas and such effect might become functionally significant in the presence or susceptibility to diabetes or NaCl. Parenteral MSG causes various changes in pancreatic islets such as hypertrophy, hyperplasia, decrease in acinar cells, α-cells and somatostatin cells and increase in fibrosis. MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility.
• In Vitro:
  Monosodium glutamate(MSG) induces apoptosis in human B cells. It has a more potent apoptotic effect in na ve B cells compared to memory B cell population. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro.
• Cell Research:
  B cells are cultured with and with out increasing concentrations of MSG(1-100 mM) for 24 h. The number of early apoptotic cells and necrotic cells is determined using Annexin-V FITC/PI staining. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mGluR1, MSG, Ionotropic glutamate receptors, Monosodium glutamate, Inhibitor, inhibit, L Glutamic acid monosodium salt, L-Glutamic acid, L-Glutamic acid monosodium, LGlutamic acid monosodium salt, iGluR, Endogenous Metabolite, Ferroptosis, Glutacyl, Glutavene, Apoptosis, Ajinomoto

Compound Identifiers

PubChem CID

23672308