L-Glutamic acid monosodium salt

SKU: orb1222704

Description

Monosodium glutamate is one of the FLAVORING AGENTS used to impart a meat-like flavor. Medically it has been used to reduce blood ammonia levels in ammoniacal azotemia, therapy of hepatic coma, in psychosis, and INTELLECTUAL DISABILITY.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 142-47-2
• MW: 169.11
• Purity: >98% (HPLC)
• Formula: C₅H₈NO₄·Na
• SMILES: C(CC(=O)O)[C@@H](C(=O)[O-])N.[Na+]
• Target: mGluR1
• Solubility: H2O : ≥ 100 mg/mL; 591.33 mM

Bioactivity

• In Vivo:
  Animal model: Crv4 mice model. Dosage: 3 g/kg. Administration: s. c. , single dose. Result: Reduced the number of Brn-3a+ RGCs by >70%. In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished. Animal model: CPF-induced rat model. Dosage: 750 mg/kg. Administration: i.p. Result: Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.
• In Vitro:
  Cell Viability Assay Cell line: SH-SY5Y, IMR-32, SK-N-BE(2). Concentration: 2, 5, 10, 20 mM. Incubation time: 24 and 48 h. Result: Reduced cell viability in a dose-dependent manner.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Monosodium glutamate | Sodium glutamate | MSG

Quick Database Links

Gene Symbol

mGluR1