L-DABA

SKU: orb1299677

Description

L-DABA is a small molecule inhibitor of GABA transaminase (GABA-T) with an IC50 exceeding 500 µM. This compound is used in neuroscience research to modulate GABAergic signaling and study the effects of elevated GABA levels in both cellular and animal models of neurological disorders.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1758-80-1
• MW: 118.13
• Purity: ≥95% (May vary between batches)
• Formula: C₄H₁₀N₂O₂
• SMILES: NCC[C@H](N)C(O)=O
• Target: GABA Receptor,Endogenous Metabolite
• Solubility: DMSO:Insoluble;H2O:Insoluble

Bioactivity

• In Vitro:
  L-2,4-Diaminobutyric acid(DABA) was a non-linear, non-competitive inhibitor of GABA transaminase activity. The DABA-induced elevation of GABA levels paralleled the inhibition of GABA transaminase activity. DABA was a more effective inhibitor of GABA transaminase in vivo than in vitro, and this inhibition probably produced the elevation of GABA levels. The neurotoxicity of DABA appears to produce a use in GABA replacement therapy.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-Aminobutyric acid Receptor, inhibit, L DABA, Inhibitor, L-2,4-Diaminobutyric acid, L-DAB HBR, LDABA, L-DABA, EndogenousMetabolite, Human Endogenous Metabolite, GABAReceptor, GABA, GABA Receptor, Gamma-aminobutyric acid Receptor, Endogenous Metabolite

Compound Identifiers

PubChem CID

134490