L-DABA hydrobromide

SKU: orb1944704

Description

L-2,4-Diaminobutyric acid hydrobromide (L-DABA HBr) is a potent and selective inhibitor of GABA transaminase. This mechanism supports its investigation in neurological research areas such as epilepsy, and it has demonstrated antitumor and anticonvulsant effects in various experimental models.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 73143-97-2
• MW: 199.05
• Purity: 99.11% (May vary between batches)
• Formula: C₄H₁₁BrN₂O₂
• SMILES: Br.NCC[C@H](N)C(O)=O
• Target: GABA Receptor,Endogenous Metabolite
• Solubility: DMSO:2 mg/mL (10.05 mM)

Bioactivity

• In Vivo:
  Treatment with L-DABA hydrobromide leads to a 43.4% reduction in tumor growth. In vivo, L-DABA hydrobromide more effectively inhibits GABA transaminase than it does in vitro.
• In Vitro:
  Incubation with 10 mM L-2,4-Diaminobutyric acid for 24 h at 37°C irreversibly and completely damages tumor cells. The cell-destructive effect caused by L-DABA hydrobromide is likely a result of osmotic lysis induced by the non-saturated intracellular accumulation of L-DABA hydrobromide. Concomitant incubation with L-alanine and L-methionine can abolish the harmful effect of L-DABA hydrobromide. Kinetic studies indicate that L-DABA hydrobromide is a non-linear, non-competitive inhibitor of GABA transaminase activity. The elevation of GABA levels induced by L-DABA hydrobromide parallels the inhibition of GABA transaminase activity. L-2,4-Diaminobutyric acid, an amino acid analogue, produces a cytolytic effect with a human glioma cell line, SKMG-1, and normal human fibroblasts. The concentrations of L-DABA hydrobromide necessary to reduce the cell count to 50% of control following a 24-h incubation at 37°C are 12.5 mM for the human fibroblasts and 20 mM for the glioma cell line.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

GABA transaminase, GABA Receptor, GABAReceptor, Endogenous Metabolite, EndogenousMetabolite, L-DABA Hydrobromide, L-2,4-Diaminobutyric acid Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide

Compound Identifiers

PubChem CID

46735201