L-Ascorbic acid

SKU: orb1310160

Description

L-Ascorbic acid

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 50-81-7
• MW: 176.12
• Purity: 99.89% (May vary between batches)
• Formula: C₆H₈O₆
• SMILES: [C@@H](CO)(O)[C@@]1(C(O)=C(O)C(=O)O1)[H]
• Target: Endogenous Metabolite|||Apoptosis|||Reactive Oxygen Species|||Calcium Channel
• Solubility: H2O:35.7 mg/mL (202.7 mM);DMSO:255 mg/mL (1447.88 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  Tyrosinase:0.96 mg/mL
• In Vivo:
  METHODS: L-Ascorbic acid (1-4.5 g/kg) was administered intraperitoneally to irradiated C57BL/6 mice to detect radioprotective activity. RESULTS: Administration of 3 g/kg L-Ascorbic acid immediately after exposure significantly increased the survival rate of mice after 7-8 Gy WBI. However, administration of less than 3 g/kg L-Ascorbic acid was ineffective, and 4 g/kg and above was harmful to mice. METHODS: To investigate the effects on amnesia, L-Ascorbic acid (60-160 mg/kg) was administered intraperitoneally to diazepam, scopolamine, and aging-induced amnesic Swiss mice once daily for 3-8 days. RESULTS: L-Ascorbic acid improved learning and memory in aging mice, as evidenced by decreased transfer latency and increased descending latency.
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• In Vitro:
  METHODS: Human osteosarcoma cells MG-63 were treated with L-Ascorbic acid (62.5-1000 µM) for 3-24 h. Cell viability was measured by XTT Assay. RESULTS: Cell viability was consistently >95% when cells were treated with L-Ascorbic acid at concentrations of 0-250 µM. When higher concentrations were used, a dose-dependent decrease in cell viability was observed. METHODS: Melanoma cells WM1366 were treated with L-Ascorbic acid (5-50 µM) for 24 h. The expression levels of target proteins were measured using Western Blot. RESULTS: The lowest concentration of L-Ascorbic acid (5 µM) significantly reduced the normoxic expression of HIF-1α protein in human melanoma cell lines.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ca2+ channels, Ca channels, Calcium Channel, CalciumChannel, cancer, Cav3.2, Ascorbic acid, antioxidant, Apoptosis, collagen, channel, donor, deposition, EndogenousMetabolite, Electron, Endogenous Metabolite, LAscorbic acid, L-Ascorbic acid, L-Ascorbate, Inhibitor, oxygen, L Ascorbic acid, L(+)-Ascorbic acid, inhibit, ROS, species, ReactiveOxygenSpecies, reactive, Reactive Oxygen Species, VC, Vitamin C

Compound Identifiers

PubChem CID

54670067