KY02111

SKU: orb1226967

Description

KY02111 promotes differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, may act downstream of APC and GSK3β.

Key Properties

• CAS Number: 1118807-13-8
• MW: 376.86
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₇ClN₂O₃S
• SMILES: O=C(NC1=NC2=CC=C(Cl)C=C2S1)CCC3=CC=C(OC)C(OC)=C3
• Target: Wnt/beta/catenin
• Solubility: DMSO: 75 mg/mL (199.01 mM)

Bioactivity

• In Vitro:
  KY02111 promotes differentiation by inhibiting WNT signaling in hPSCs. KY02111 induces cardiomyocytes expressed the cardiac markers, αMHC, NKH2.5, and HCN4.KY02111 (1-10 μM; 12 hours, 24 hours) reduces WNT signaling in both IMR90-1 cells and HEK293 cells in a dose-dependent manner. KY02111 treatment with WNT signaling modulators produces robust cardiac differentiation of hPSCs in a xeno-free, defined medium, devoid of serum and any kind of recombinant cytokines and hormones, such as BMP4, Activin A, or insulin.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KY02111 | KY 02111 | KY-02111

Quick Database Links

Gene Symbol

Wnt/beta/catenin